The Beta-Lactam Antibiotics - SlideServe
The Beta-Lactam Antibiotics - SlideServe
Dec 20, 2011
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Beta-Lactams (Penicillins & Cephalosporins): Excellent first-line choice as they target the bacterial cell wall, a structure absent in human cells. Macrolides: Azithromycin is well-studied and a reliable option. 💡 Special Consideration: Nitrofurantoin for UTIs A great choice for treating UTIs, but with important timing considerations: Use with caution in the early 1st trimester. Avoid at term (38-42 weeks) due to the risk of neonatal hemolytic anemia. It's safest during the 2nd and early 3rd tr
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Beta-lactam antibiotics are a group of antibiotics that contain a beta-lactam ring as a common chemical feature. They disrupt the synthesis of the bacterial cell wall. Beta-lactam antibiotics inhibit bacterial cell wall synthesis. Due to the structural similarity to D-alanyl-D-alanine, beta-lactam antibiotics act as substrate analogues by covalently binding to the serine in the transpeptidase active site. In this way, they irreversibly block the enzyme that is essential for cell wall synthesis.
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