medicoshub on Instagram: "🧠 Parkinson’s Disease – Understanding the Festinating Gait In Parkinson’s disease, degeneration of dopaminergic neurons in the substantia nigra pars compacta leads to classic Parkinsonian symptoms—resting tremor, rigidity, bradykinesia, and changes in gait. 🚶‍♂️ Festinating Gait is a hallmark feature: • Short, small shuffling steps • Steps may rapidly accelerate • Often preceded by freezing episodes, where the patient struggles to initiate movement This gait pattern o

Ischemic stroke: Causes, symptoms, and risk factors

Classify Rx on Instagram: "📍 Blood-Brain Barrier Penetration Domperidone = minimal BBB crossing → lower CNS side effects (less EPS, sedation, drowsiness). Metoclopramide = readily crosses BBB → higher risk of extrapyramidal symptoms (dystonia, akathisia, tardive dyskinesia). 📍 Extrapyramidal Risk Trade-off Metoclopramide’s central D2 antagonism causes acute dystonia, parkinsonism, and irreversible tardive dyskinesia (especially elderly, prolonged use). Domperidone’s peripheral action spares pa