Glial Cell Communities Conspire to Drive Alzheimer’s Disease
Sep 26, 2024 · The amyloid cascade—plaques to tangles to cognitive decline—has become well established. Less well understood is what role inflammation and glial changes play. Now, by …
Glial lipid droplets resolve ROS during sleep. | ALZFORUM
Feb 27, 2024 · Most previous work on this process focused on disease conditions. However, Haynes and colleagues discovered that glial lipid droplet accumulation occurs as part of a daily rhythm: in …
Amelioration of Tau and ApoE4-linked glial lipid ... - ALZFORUM
Nov 29, 2023 · Here, Alexandra Litvinchuk from David Holtzman’s laboratory investigated the effect of the LXR agonist GW3965 as well as overexpression of ABCA1 on tau and apoE4-linked glial lipid …
Sans Plexin-B1, Glial Net Tightens Around Plaques - ALZFORUM
Jun 1, 2024 · Plexin-B1 expression by astrocytes imposes cell spacing in glial nets. Without Plexin-B1, glia huddle more closely together, and with plaques. The result? Smaller plaques, protected …
New Role for Tau: Making Lipid Droplets in Glia? | ALZFORUM
Oct 22, 2024 · When they cranked up tau expression in glia throughout the fly brain, glial lipid droplets plummeted by more than 90 percent, and peroxidated lipids accumulated. Similarly, in co-cultures of …
“iAssembloids” Probe Glial Roles in Neuron Survival
Jan 24, 2025 · Interestingly, they discovered that this axis is undetectable in 2D or even 3D neuron monoculture models, highlighting the need for more sophisticated models replicating physiological …
Tau is required for glial lipid droplet formation and resistance to ...
Oct 22, 2024 · This very interesting finding describes a novel function for tau in the processing of peroxidated lipids from neurons. We previously showed that these lipids are transferred from …
Stirred by Tau, Neurons Amp Up Lipid Droplets in Glia
Apr 30, 2024 · Lipid droplets accumulate in microglia in mouse and cell models of amyloidosis but scientists are not sure why. Evidence suggests that Aβ helps create the glut, but now scientists led …
Glial AP1 is activated with aging and accelerated by ... - ALZFORUM
Byrns CN, Saikumar J, Bonini NM. Glial AP1 is activated with aging and accelerated by traumatic brain injury. Nat Aging. 2021 Jul;1 (7):585-597. Epub 2021 Jul 8 PubMed.
Engineered 3D Immuno-Glial-Neurovascular Human Brain Model
Stanton AE, Bubnys A, Agbas E, James B, Park DS, Jiang A, Pinals RL, Truong N, Loon A, Staab C, Liu L, Cerit O, Wen H-L, Kellis M, Blanchard JW, Langer RS, Tsai L-H. Engineered 3D Immuno-Glial …