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The US administration has extended its line of attack on academia from US federal research to private universities. The abuse ...

Although student mobility is being restricted in a less dramatic fashion than currently in the USA, the impact on science ...

This study highlights novel genotype-driven metabolic adaptations in PM, laying the groundwork for targeted interventions ...

imageimageFat tissue is a central organizer of systemic lipid homeostasis and obesity. This study identifies adipocyte-specific cell surface protein NRAC as a rheostat for CD36 scavenger ...

imageimageThis study developed a systematic workflow leveraging transcriptomics and metabolomics to identify input signals for 41 transcription factors in E. coli. A systematic workflow was developed ...

Sixteen Gα-subunits transduce hundreds of G protein-coupled receptors and control countless cellular activities. Mutations in respective GNA genes underlie developmental, oncological, metabolic, ...

imageimageOncogenic YAP accelerates S-phase entry by shortening G1, leading to replication stress and sensitivity to CHK1 inhibition. This vulnerability can be targeted by modulating CDK4/6 activity ...

While SMAD7 has been widely studied in liver and kidney fibrosis—where it dampens TGF-β activity and restrains inflammation-driven ECM accumulation—recent evidence highlights its relevance in cardiac, ...

image image Simultaneous targeting of the immunoproteasome subunits LMP2 and LMP7 is required for optimal therapeutic efficacy in the treatment of autoimmunity. These findings will promote the design ...

imageimageRibosomal quality control (RQC) ubiquitin ligase ZNF598 distinguishes transient ribosome collisions from permanent ones. Here, simultaneous imaging of protein-mRNA binding dynamics and ...