49ers head coach Kyle Shanahan told reporters Monday that McCaffrey suffered a posterior cruciate ligament (PCL) injury during Sunday's 35-10 loss to the Buffalo Bills, and will be placed on injured reserve as result. McCaffrey's recovery is expected to be six weeks, meaning that the rest of his season is in jeopardy.

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San Francisco 49ers star running back Christian McCaffrey suffered a PCL injury and is expected to miss six weeks, head coach Kyle Shanahan told

Christian McCaffrey may be done for the rest of 2024. Following Sunday’s 35-10 loss to the Bills, 49ers head coach Kyle Shanahan told reporters in his postgame press conference that McCaffrey suffered a PCL injury that could be season-ending.

Christian McCaffrey's season might be over as he, along with backup running back Jordan Mason, will be placed on injured reserve.

The worst fears for the San Francisco 49ers and star Christian McCaffrey may have been realized, as the star running back exited Sunday’s snowy game in Buffalo with a non-contact injury.

McCaffrey suffered a potentially season-ending PCL injury, 49ers coach Kyle Shanahan said after the 35-10 loss to the Bills. McCaffrey took a toss, limped a couple steps and slid to the ground to give himself up for a 5-yard loss. He got to his feet and gingerly jogged off the field and into the blue medical tent.

The San Francisco 49ers will place star running back Christian McCaffrey on season-ending injured reserve with a PCL injury.

Among the NFL players who suffered injuries in Week 13, Baker Mayfield entered that unwanted mix. And Taysom Hill took a bad injury. But leading the high-profile way on the injury list, Christian McCaffrey and Trevor Lawrence both failed to finish their respective contests.