RNA-guided CRISPR system activates gene expression

In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally ...
IEEE

Protein-Binding RNA Prediction Based on Integrated Sequence-Structure-Function Pre-Training

Abstract: RNA binding proteins (RBPs) play a crucial role in regulating biological functions through their interactions with specific RNAs, significantly impacting various life processes.
EurekAlert!

Finding a function for glycosylated, cell surface RNA

The recent discovery of glycoRNAs on the cell surface upended the world of cell biology. These glycoRNAs were found to form highly organized clusters with cell surface RNA binding proteins (csRBPs), ...
Medical Xpress

Genetic Function: RNA Methylation

Cancer cells are relentless in their quest to grow and divide, often rewiring their metabolism and modifying RNA to stay one step ahead. Now, researchers at the UCLA Health Jonsson Comprehensive ...
Business Wire

Elegen and Nutcracker Therapeutics to Pilot First Fully Cell-Free Manufacturing Process for RNA-based Personalized Cancer Therapeutics

Fully cell-free process aims to further democratize personalized cancer therapeutic manufacturing with shorter turnaround times and negligible bioburden and endotoxin risks. As late-stage PCT clinical ...
PNAS

DNA polymerase α-primase can function as a translesion DNA polymerase

Eukaryotic Polα-primase contains DNA polymerase (Pol1) and RNA primase subunits that together synthesize a >20-nucleotide hybrid RNA–DNA primer. Bacteria and archaea only require a dozen or less RNA ...
The New York Times

Twins trade deadline primer: How team’s sale could impact front office’s ability to function

With the July 31 trade deadline fewer than seven weeks away, let’s take a look at how the Twins could attempt to restock their roster for the stretch run as the market and trade rumors start to heat ...
ascopubs.org

The role of ADAR1-mediated A-to-I RNA editing and non-editing functions in radioresistance of esophageal squamous cell carcinoma.

A systemic trend analysis of young onset esophageal cancer in American population, 2012-2021. Comparison of capecitabine plus oxaliplatin (CAPOX) vs paclitaxel plus carboplatin (PC) as chemotherapy in ...
technologynetworks

Disruption of RNA Binding Proteins Impairs Regulatory T-Cell Function

Immunologists from the Babraham Institute have been the first to uncover a role for a family of RNA-binding proteins in the function of regulatory T cells in the immune system. As their name suggests, ...