The Chiefs were the first team to clinch an NFL playoff berth, but the Bills can one-up them by sealing the AFC East with a win over the 49ers.

Here's where the 49ers sit in the 2025 NFL Draft order after San Francisco's 35-10 blowout loss to the Buffalo Bills on Sunday at Highmark Stadium.

The BetMGM bonus code is FPB50 for NFL betting and it offers an exclusive welcome bonus worth up to $1,550 for the Buffalo Bills vs. San Francisco 49ers on Sunday Night Football (8:20 p.m. ET on NBC).

Sunday Night Football prop picks and NFL SGP for San Francisco 49ers vs. Buffalo Bills for sites like PrizePicks, Underdog Fantasy, DraftKings, Pick6, and more

San Francisco 49ers quarterback Brock Purdy is expected to play Sunday night against the Buffalo Bills, according to ESPN's Adam Schefter. Purdy was

Two sides stuck on losing streaks meet at the Levi's Stadium in Game Week 14.  The Buffalo Bills comfortably beat the 49ers amidst a snowy

After sparking the 49ers with a handful of impressive runs, Christian McCaffrey looked like himself early in the game against the Buffalo Bills. On seven carries, McCaffrey rushed for 53 yards to go along with a pair of catches for 14 yards against the Bills.

Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.

Russell Wilson turned back the clock as the Pittsburgh Steelers won a 44-38 shootout over divisional rival Cincinnati on Sunday. “It was fun. We just had a great time,” Wilson said via The Associated Press.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night.