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NFL Week 16 kicks off on Thursday, as the Seahawks host the Rams. Here are the lines for every Week 16 matchup at DraftKings Sportsbook as of Dec. 21. This page may contain affiliate links to legal ...

The Indianapolis Colts will enter their Monday Night matchup against the San Francisco 49ers as the home underdogs. At 8-6 on the season, the Colts have lost four consecutive games and five of six ...

NFL Week 16 odds open with one of the best contests of the year as the Seattle Seahawks look to enact a bit of revenge over the Los Angeles Rams on Thursday Night Football. Week 16 also features a ...

The Arizona Cardinals play their final home game of the season on Sunday in Week 16. They host the 5-9 Atlanta Falcons, kicking off from State Farm Stadium at 4:05 p.m. ET (2:05 p.m. Arizona time).

We might be getting to the point in the NFL season in which some of the worst teams aren't capable of covering a big spread. There were five double-digit underdogs last week. Four of them failed to ...

One of the most effective ways to make picks against the spread in the NFL is by targeting the opening lines. By securing a favorable price early in the week, you can maximize your chances of staying ...

Justin Herbert and the Chargers opened as 2.5-point underdogs in Week 16. IMAGN IMAGES via Reuters Connect Gambling content 21+. The New York Post may receive an affiliate commission if you sign up ...

The NFL Week 16 schedule has 16 games and some very interesting betting lines. What do NFL betting odds say about each game this week, the 16th week of the 2025 NFL regular season? Who is favored in ...