The completion of mitosis is governed by the dephosphorylation of cyclin-dependent kinase (Cdk) substrates and by the ubiquitination of anaphase-promoting complex (APC) substrates. The order in which ...
USP28 and 53BP1 proteins form a complex to stabilise the tumour suppressor p53, which is required to protect cells from mitotic stress and subsequent genome instability. Here, the authors discover ...
Bacteria are amongst the simplest of organisms – they are made of single cells. Their cell structure is simpler than the cells of animals, plants and fungi.