Some people breeze through their 70s with the vitality of someone decades younger, while others visibly decline. Ditto for their organs. Time and genetics explain some of this wear and tear, but does ...
More than 300 mutations in PSEN1 have been catalogued, but none are quite like the one Bart De Strooper and colleagues at the Flanders Institute for Biotechnology in Leuven, Belgium, reported on ...
Contact Information Subodh Verma, M.D., Ph.D., FRCSC, FAHA, FCAHS Toronto, CanadaProfessional Information ProfessorUniversity of Toronto ...
Could stem cells step in to replace lost neurons in Parkinson’s disease? In three Phase 1 clinical trials, scientists tested lab-grown dopaminergic cells in small cohorts to assess safety and look for ...
The APOE4 allele heightens the risk of Alzheimer’s disease in several ways. Here’s a new one: It may deprive neurons of a crucial fuel. In the October 16 Nature Metabolism, scientists led by Thomas ...
Low-intensity transcranial focused ultrasound is a noninvasive, targeted neuromodulation technology. It uses mid- or low-frequency sound waves delivered from arrays applied to the outside of the head ...
The gene PSEN2 encodes presenilin-2, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. Missense mutations in PSEN2 are a rare cause of early onset Alzheimer's disease.
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We have developed this special section of the Alzforum website to provide a resource for all who share an intense interest in familial early-onset AD (eFAD). We have created this series of articles ...
APOE4 was originally studied in the context of blood lipids and cardiovascular disease and first characterized at the protein level as one of three inherited ApoE isoforms with unique ...
Building 114, Suite 2011 16th Street Charlestown, MA02129 United States Visit Website Contact: Bradley T. Human, M.D., Ph.D. Phone: (617) 726-3987 E-mail: [email protected] Brain Banks Home ...
To mark the 20th anniversary of Alzforum's launch in 1996, we have compiled a timeline reflecting the evolution of Alzheimer’s disease research, starting from Alois Alzheimer's public presentation of ...