Adenylosuccinate lyase (ADSL) deficiency is an inherited metabolic disorder that impairs purine metabolism. ADSL is a key enzyme in both the de novo synthesis and the purine nucleotide cycle, ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 70, No. 12, Part II (1973), pp. 3880-3883 (4 pages) Purine metabolism has been examined in a clonal line of mouse ...

Metabolism is known for its intricate adjustments to meet the needs of an organism. Due to demands of adaptation, parasite metabolic pathways are greatly altered from those of their hosts. A key ...

Researchers have used machine-learning algorithms to discover a secondary mechanism that helps some antibiotics kill bacteria. This mechanism involves disrupting bacterial metabolism of nucleotides ...

Nucleotides are essential components of a wide range of cellular processes; therefore, the maintenance of these levels through various metabolic pathways is crucial for adequate cellular function. The ...

An international study by the Institute of Neuroscience of the UAB (INC-UAB), Emory University and Hospital Universitario La Paz, published in the PNAS journal, shows that patients suffering from ...