Using ultra-bright X-ray flashes, a team of researchers has tracked down a potential target for new drugs against sleeping sickness: The scientists have decoded the detailed spatial structure of a ...

Trypanosoma brucei, the causative agent of African sleeping sickness, represents a paradigm of parasite evolution and immune evasion. Its ability to periodically change its variant surface ...

Bloodstream forms of Trypanosoma brucei brucei were grown over baby hamster kidney cells in minimum essential medium with various concentrations of metronidazole (Flagyl) and chloroquine. Both drugs ...

Polyamines are essential for proliferation of Trypanosoma brucei brucei, and feeding rats polyamine-deficient chow (PDC) decreases their blood polyamine concentrations. Proliferation of T. b. brucei ...

Trypanosoma are a nasty class of single-celled parasites that cause serious, even fatal, diseases in human and animals. Two species cause sleeping sickness, a disease that threatens all of ...

Trypanosomes are parasites that cause deadly diseases in humans and animals, such as Human African Trypanosomiasis (sleeping sickness), Chagas disease, and Nagana in cattle. According to the World ...

A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health sheds light on how the blood-borne parasite that causes African sleeping sickness in humans and related diseases ...

Trypanosoma brucei infection induces fat breakdown, but this strategy benefits the host. To uncover how the parasite induces fat loss, the researchers used wildtype and knockout mice that lacked ...

The T. brucei genome sequence previously used for research was obtained from a bovine infecting strain, harmless to humans. The team sequenced the entire genome of the pathogenic subspecies T. b.

If left untreated, African Sleeping Sickness can causes meningoencephalitis, coma, and death. The disease is spread through tsetse flies that feed on infected hosts. In 2015, 84 percent of Trypanosoma ...

Infections can present with many different symptoms, and one common symptom is wasting, which involves the loss of fat and in extreme cases lean muscle as well. Researchers in the lab of Salk ...