As technologies and methodologies advance, so do the potential applications for biospecimens. In this article, we explore seven uses of FFPE, ranging from the common to the cutting-edge.

Scientists from Spain have recently compared the efficacy of the quantitative polymerase chain reaction (qPCR) method and immunohistochemistry in detecting severe acute respiratory syndrome ...

For the first time, Fox Chase Cancer Center researchers have demonstrated the ability to extract RNA from formalin-fixed, paraffin-embedded tissue samples archived for up to five years. For the first ...

An invaluable source of RNA, DNA, and chromatin from historical and clinical samples is formalin fixed paraffin embedded (FFPE) tissue. Globally, tissue banks, hospitals, and laboratories are ...

Immunoperoxidase and immunofluorescence techniques detected and localized infectious bursal disease virus (IBDV) in formalin-fixed paraffin-embedded sections of the bursa of Fabricius of ...

Formalin-fixed paraffin-embedded (FFPE) tissues are the most widely used clinical sample types in histology and molecular diagnosis. However, due to RNA degradation and protein crosslinking, FFPE ...

Circulating tumor cells as a surrogate marker for determining response to chemotherapy in Japanese patients with metastatic colorectal cancer. Background: miRNAs have been shown to be involved in ...

Global micro-RNA (miR) profiling of human malignancies is increasingly performed, but to date, the majority of such analyses have used frozen tissues. However, formalin fixation is the standard and ...

The relatively new field of onco-metabolomics attempts to identify relationships between various cancer phenotypes and global metabolite content. Previous metabolomics studies utilized either nuclear ...

A single-arm trial of panitumumab in cetuximab refractory KRAS wild-type colorectal cancer. Background: Genomic profiling has improved our understanding of the underlying biology of tumors, accuracy ...

This is a preview. Log in through your library . Abstract For specific demonstration of Rickettsia rickettsii in fixed, paraffin-embedded tissues, the technique of trypsin digestion of deparaffinized, ...