Unraveling DNA polymerase’s activity can help scientists better understand DNA replication and repair and explore how these processes fail and lead to diseases, such as cancer. “This finding [happened ...

MSK researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer.

More information: Tyler M. Maclay et al, The DNA replication checkpoint targets the kinetochore to reposition DNA structure-induced replication damage to the nuclear periphery, Cell Reports (2025).

A breakthrough enzyme aims to resolve a persistent DNA artifact that has challenged forensic analysis for decades.

The manipulation of DNA replication and the adoption of advanced gene-editing technologies illustrate a remarkable convergence of scientific innovation and ethical considerations.

How chromatin responds to transcription-blocking DNA lesions is unclear. This study reveals that RNA polymerase II (RNAPII) ...

A research group led by the University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in ...