The coffee paradox in adenosine-mediated antidepressant action. Depression (left) and coffee consumption (right) are both linked through adenosine signaling (center), creating a pharmacological ...

Adenosine Signaling: Convergent Mechanisms for Rapid Antidepressants. Three distinct interventions—ketamine (pharmacological), electroconvulsive therapy/ECT (electrical), and acute intermittent ...

Depression continues to grip roughly 332 million people worldwide, according to World Health Organization estimates. While standard antidepressant medications offer relief for many, nearly half of ...

Pannexin channels are integral membrane proteins that form large-pore channels, facilitating the release of adenosine triphosphate (ATP) into the extracellular space. This ATP release is pivotal in ...

Adenosine Is A Metabolic Common Pathway Of Rapid Antidepressant Action: The Coffee Paradox. EINPresswire/ -- Perhaps the most intriguing implication of recent breakthrough research lies in an ...