O’Donnell has openly discussed her weight loss journey on social media. In January 2023, she shared on TikTok that she had started taking Mounjaro, an FDA-approved prescription medication for people with type 2 diabetes, which helps with weight loss by reducing appetite and improving how the body breaks down sugar and fat.

Rosie O'Donnell shared a new photo showing off her dramatic weight loss after undergoing a body transformation, revealing she is 'shocked' to be a size 12

Presenter and actress Rosie O'Donnell is the latest celeb to show off the results of taking Mounjaro for her diabetes

She looked incredible in a black sweat suit, although she admitted she “was undecided." "I can't see myself in this new, smaller body," she wrote. She revealed that she is now a size 12, writing, Mounjaro is a "lifesaver.

The 63-year-old comedian exclusively told Page Six in April that she has lost “an average of one to two pounds per month” on semaglutide.

Rosie O'Donnell has shared the latest step in her weight-loss journey, writing that she's "shocked" at her new clothing size.

Rosie O’Donnell, who accomplished a massive weight loss in recent times, was left “shocked” by her new clothing size at a store. The Exit to Eden star later took to social media to share her surprise and joy with the fans.