Sirtuins are a family of NAD⁺-dependent deacetylases and ADP-ribosyltransferases that regulate cellular metabolism, stress responses and genomic stability. In the central nervous system, these enzymes ...

Animals on the early branches of the tree of life, such as jellyfish and sea sponges, defy the usual conventions of aging. Some show abilities to regenerate damaged or missing tissues, halt or reverse ...

Sirtuins (SIRT1–7) are a family of NAD+-dependent deacetylases that regulate key cellular processes including mitochondrial function, oxidative stress response, autophagy and inflammation. In the ...

Emerging longevity research suggests the body’s stress-response proteins could play a bigger role in healthy aging than previously thought. Sirtuins are sometimes described as the body’s “longevity ...

New insights into a family of metabolites, acylspermidines, could change how we understand aging and fight disease. A new study presents an unexpected connection between spermidine, a long-known ...

“This work suggests that preservation of microglia and Sirt1 binding activity and patterns, as well as the directionality of pathways regulated by Sirt1, are prognostic of long-living.” The aging ...

Beyond all empty promises of miracle drugs, it has been clear for decades that there is indeed a simple way to extend lifespan, though not one that most people who have a choice are particularly ...

A new study adds fuel to the fire against the notion that a class of proteins called sirtuins can prolong life. The proteins generated significant excitement when earlier studies showed they could ...

Cardiovascular disease (CVD) refers to a group of disorders affecting the heart and blood vessels and is a leading cause of death globally. Lifestyle factors have been linked to the incidence of CVD ...

Jellyfish, sea sponges, amoebas and other animals on the early branches of the tree of life defy conventional aging. A new study reveals diversity of proteins called sirtuins in these animals compared ...

Caloric restriction influences cardiac health through the involvement of sirtuin proteins. Future research on CR and sirtuins may result in the development of novel CR mimetics to manage and treat CVD ...