Mitochondria have critical cellular functions including energy mobilization, calcium regulation, metabolite production and redox homeostasis 1,2. However, mitochondrial proteins are challenged by ...

Cilia are antennae-like vestigial organelles that project from the outside of virtually all eukaryotic cells. Primary cilia are typically non-motile, sense extracellular signals, and act as regulators ...

A significant step forward in protein design from Generate Biomedicines, Massachusetts, has developed an AI that can generate feasible protein structures and predict the potential functionality of the ...

Aquaglyceroporin Aqp10, a protein channel for water and glycerol, selectively permeates urea and boric acid due to its unique structural features—report researchers from Japan. By comparing and ...

Proteomics is the large-scale study of proteins, particularly their structures and functions. It involves the systematic identification, quantification, and analysis of the entire protein complement ...

In genetics, one harmful variant can be enough to cause disease—but two can make it far more severe. One notable example is KJ, an infant diagnosed with a rare urea cycle disorder with a grim ...

This fully updated volume explores a wide array of new and state-of-the-art tools and resources for protein function prediction. Beginning with in-depth overviews of essential underlying computational ...

A new LMU study shows how proteins function reliably even without a stable 3D structure – and the crucial importance not only of short sequence motifs, but also of the chemical characteristics. Many ...

A grayscale ribbon representation of a protein with space filling representations of a steroid (orange) and β-lactamase active site (green). One of the hormone-binding protein switches Credit: Kirill ...

After nearly four decades of research, Mayo Clinic scientists have revealed the molecular structures of protein kinase C beta ...