Chemotherapy drugs that target cancer cells without damaging normal cells remain one of the key goals of precision medicine in cancer treatment. The challenge is designing drugs that do this ...

Study reveals that reversible chemical modifications can inhibit pyruvate kinase and affect its variants differently, ...

Researchers studied synthetic lethality pathway using Promega NanoBRET ® TE technology Study is the first to characterize uncompetitive binding directly in live cells, illuminating a mechanistic ...

A feature of pancreatic cancer cells' surroundings determines whether they grow fast or become resistant to chemotherapy, a new study shows. The ability of these cancer cells to adapt quickly and ...

Scientists have identified a mirror-image form of the amino acid cysteine that selectively slows the growth of certain ...

Nucleotide synthesis-the production of the basic components of DNA and RNA-is essential for cell growth and division. In most animal cells, this process depends closely on properly functioning ...

Researchers suggest targeting ECM-mediated regulation of autophagy levels could be used to sensitize pancreatic cancer to FDA-approved therapies.

Nucleotide synthesis—the production of the basic components of DNA and RNA—is essential for cell growth and division. In most ...