Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance. St. Jude Children's Research Hospital scientists have identified specific DNA variants in the ...

We adapted Tn5 transposition to reduce the amount of input DNA required for amplification-free single-molecule real-time Pacific Biosciences sequencing. We applied transposition-based library ...

Third-generation single-molecule sequencing (SMS) technologies deliver accurate, multimodal readouts of genetic sequence and nucleobase modifications on kilobase (kb)-length to megabase-length nucleic ...

(L to R) Co-first author Jackson Mobley, PhD, corresponding author Daniel Savic, PhD, and co-first author Kashi Raj Bhattarai, PhD, all of the St. Jude Department of Pharmacy and Pharmaceutical ...