Naloxone, also known by the brand name Narcan , is one of the most important drugs in the United States' fight against the ...

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions, current medications have several limitations, ...

We report that opioids from the inflamed colon activate δ-opioid receptors (DOPr) in endosomes of nociceptors. Biopsy samples of inflamed colonic mucosa from patients and mice with colitis released ...

Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid (pronounced “mew-opioid”) receptors. What they didn’t know — until now — was ...

The human body naturally produces opioid-like substances, such as endorphins, which block the perception of pain and increase the feeling of well-being. Similarly, opioid drugs, including morphine or ...

Partial opioid agonists have mixed or limited action when they bind to your opioid receptors. So, doctors often use them to treat opioid use disorder. Protein receptor sites are like keyholes on the ...

Sublocade (buprenorphine) is a brand-name subcutaneous injection prescribed for opioid use disorder. It works to help reduce the need for opioids by acting in certain areas of the brain called mu and ...