Understanding a drug’s mechanism of action (MOA) can greatly increase the likelihood of successful clinical trials by identifying biomarkers of patient response and providing a rationale for ...

The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the neurochemical ...

Biomarkers are key to the development of biological drugs, offering vital insights into drug mechanisms of action (MOA), informing clinical study design, and optimizing treatment strategies.

Malaria represents one of the most serious threats to human health worldwide, and preventing and curing this parasitic disease still depends predominantly on the administration of a small number of ...

Researchers have revealed the mechanism of the drug valemetostat shown to be effective in treating certain types of cancer by targeting a protein modification (histone methylation) silencing the ...

Conventional cancer drugs work by triggering apoptosis, that is programmed cell death, in tumor cells. However, tumor cells have the ability to develop strategies to escape apoptosis, rendering the ...

Blarcamesine, Aricept, and most probably simufilam are sigma-1 receptor agonists. Sigma-1 receptor agonists often produce temporary improvements in cognition for those with mild cognitive impairment ...