Human gut organoids with (left) and without (right) the transcription factor ZNF800. On the left, wild type (unaltered) gut organoids show the presence of goblet cells (green), enteroendocrine cells ...

Researchers have unveiled an intriguing phenomenon of cellular reprogramming in mature adult organs, shedding light on a novel mechanism of adaptive growth. The study, which was conducted on fruit ...

A multi-institutional group of researchers led by the Hubrecht Institute and Roche's Institute of Human Biology has developed strategies to identify regulators of intestinal hormone secretion. In ...

Crypt-base-columnar cells are continuously dividing intestinal stem cells that generate IECs, which are composed by distinct specialised cell types that play different functions: Enterocytes (in the ...

New research reveals how plant-based flavonoids can regulate gut hormones like GLP-1 and ghrelin, offering a natural strategy to manage insulin resistance and slow the progression of type 2 diabetes.