In a study published in the journal Nature Metabolism, researchers treated male mice on a high-fat diet (HFD) with an inhibitor of mitochondrial transcription (IMT). They found that this shifted the ...

Carboxylesterases are a class of enzymes that play a pivotal role in the metabolism of a wide array of endogenous and exogenous compounds. Predominantly expressed in the liver and intestine, these ...

The liver is the principal site of the body's drug metabolism, so it isn't surprising that drug-induced liver injury (DILI) can occur. However, despite the common use of medications in today's society ...

The liver is accountable for metabolizing most medications and is therefore one of the primary tissues affected by adverse drug reactions. Most classes of medicine can cause drug-induced liver injury ...

A promising “two-in-one” experimental drug could tackle both type 2 diabetes and heart disease by slashing cholesterol and ...

A team from Barcelona discovered that two existing drugs can safely reverse liver fat buildup in MASLD. The combination targets multiple pathways, potentially transforming treatment for fatty ...

The supplement industry is booming—but so are serious health issues tied to taking these pills and powders. Here’s what ...

The FDA approved the first drug to treat a severe form of liver disease earlier this year, which was developed through research conducted by a Duke professor. The drug, resmetirom, is a novel ...

A recently developed amino acid compound successfully treats nonalcoholic fatty liver disease in non-human primates — bringing scientists one step closer to the first human treatment for the condition ...