ALSPAC is able to link participants’ self-reported data with external data sources to further strengthen the resource and enable life-changing research. Many of these linkages are in place and the ...

The Office for National Statistics (ONS) has published a review of data-linking practices across government, and elsewhere, in order to make data more useful for government decision-making. The ...

Whole-exome sequencing (WES) has become the strategy of choice to identify causal variants in monogenic disorders. However, the list of candidate variants can be quite large, including false positives ...

Recent advances in next-generation sequencing (NGS) make it possible to directly sequence genomes and exomes of individuals with Mendelian diseases and screen sequence data for causal variants. With ...