RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions ...

In short, two proteins called 53BP1 and RIF1 engage to build a three-dimensional “scaffold” around the broken DNA strands. This scaffold then locally concentrates special repair proteins, that ...

The study demonstrates how these proteins collaborate in so-called “hubs” to repair DNA damage. These findings may lead to new cancer therapies and other treatments where DNA repair is essential.

A research team has successfully identified a novel DNA damage repair pathway in human cells. This study is the first to ...

The research, conducted by neurobiologist Dr Sina Shadfar and colleagues in the Motor Neuron Disease Research Centre, reveals a protein called protein disulphide isomerase (PDI) helps repair serious ...

DNA repair proteins act like the body’s editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

This scaffold then locally concentrates special repair proteins, that are in short supply, and that are critically needed to repair DNA without mistakes. 'It's a unique discovery.

Surprisingly, they found that although the mutated helper proteins could not switch on Rad51 in a test tube, yeast cells with these mutations were still able to repair their DNA without problems.

A new discovery offers hope for Huntington’s disease. This discovery provides hope that a DNA repair process may help slow or stop disease progression.

Review Published: 18 December 2007 The DNA damage response pathways: at the crossroad of protein modifications Michael SY Huen & Junjie Chen Cell Research 18, 8–16 (2008) Cite this article ...

“This family of proteins is the most exciting protein family now in biology,” said He, who led the study. “These proteins directly impact obesity, cancer and diabetes, and they do not go through the ...