Environmental Health Perspectives, Vol. 115, No. 4 (Apr., 2007), pp. 513-518 (6 pages) Background: Arsenic contamination has become a major public health concern worldwide. Epidemiologic data show ...

Mitogen-activated protein kinases (MAPKs) are part of an intracellular signaling machinery consisting of three known distinct pathways, each leading to activation of a different protein kinase: p38, ...

Cyclooxygenase–2 (COX-2) is upregulated in many tumors including neuroblastoma, and its overexpression has been implicated in resistance to p53-dependent apoptosis. Although p53 is rarely mutated in ...

Arachidonic acid (ARA) is metabolized by cyclooxygenase (COX) and cytochrome P450 to produce proangiogenic metabolites. Specifically, epoxyeicosatrienoic acids (EETs) produced from the P450 pathway ...

Reducing Xerostomia by IMRT: What May, and May Not, Be Achieved Since 1992, there have been approximately 10,962 COX-2–related publications and many studies of human cancer have associated its ...

COX-2 plays a pivotal role in ferroptosis during the progression of chronic liver disease, as it downregulates the Nrf2 signaling pathway, exacerbating ferroptosis, which is characterized by ferrous ...