The inefficiency induced by between-cluster variation in cluster randomized (CR) trials can be reduced by implementing a crossover (CO) design. In a simple CO trial, each subject receives each ...

A cluster randomised trial (CRT) is a randomised controlled trial in which pre-existing groups, called clusters, of individuals are randomly allocated to treatment arms. For example, clusters may be ...

In this week's PLOS Medicine, Charles Weijer and colleagues present the Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials, which aims to provide researchers and research ...

To assess the efficacy of a school-based intervention programme to reduce the prevalence of overweight in 6 to 10-year-old children. The prevalence of overweight and obesity decreased by 3.2% (from 20 ...

Allogeneic Hematopoietic Cell Transplantation Improves Outcome in Myelodysplastic Syndrome Across High-Risk Genetic Subgroups: Genetic Analysis of the Blood and Marrow Transplant Clinical Trials ...

Background: Sophisticated approaches are needed to improve the quality of care for elderly people living in residential care facilities. We determined the effects of multidisciplinary integrated care ...

In an open-label, two-period, two-sequence, cross-sectional, cluster-randomized, crossover trial, we assigned hospitals in Ontario, Canada, to use either lactated Ringer’s solution or normal saline ...

Objectives: We assessed whether proactive care management for artificial intelligence (AI)–identified at-risk patients reduced preventable emergency department (ED) visits and hospital admissions (HAs ...

Adjuvant Nivolumab in High-Risk Muscle-Invasive Urothelial Carcinoma: Expanded Efficacy From CheckMate 274 Sixteen towns in Sihui and Zhongshan cities, China, were selected; eight were randomly ...