Understanding how regulatory T cells (Tregs) develop and work is key to determining how they might be manipulated to encourage the destruction of cancer cells or prevent autoimmunity. Cell behavior is ...

Genome-wide chromatin accessibility profiling reveals how myelodysplastic syndrome (MDS) stem cells progressively lose normal stem-cell features and acquire myeloid progenitor-like characteristics.

Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) have identified key changes to both chromosome structure and gene expression that affect stem cell function during aging. Using ...

Individual variation in fertility, growth and behavior characteristics is a common phenomenon observed in mammals. Among these individual variations, fertility variation attracts more people attention ...

Researchers from the University of Chicago (IL, USA) have reported that unstable, or ‘noisy’, chromatin enables cells to take on different roles in the body. This flexibility can support the immune ...

Immune cells in the blood may be intimately involved with Alzheimer’s pathogenesis in the brain. At least, according to their chromatin. A study published January 31 in Neuron reported that in people ...

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave. Researchers have now mapped this hidden architecture in unprecedented detail, showing ...

Complementary value of a digital pathology biomarker to post-surgery circulating tumor DNA in risk stratification of stage III colon cancer patients receiving adjuvant chemotherapy. This is an ASCO ...