Nigel Killeen, Craig B. Davis, Keting Chu, M. E. Casey Crooks, Shinichiro Sawada, John D. Scarborough, Kevin A. Boyd, Susan G. Stuart, Hua Xu and Dan R. Littman https ...

Researchers of this new study found that treatment with venetoclax may be able to restore activation and proliferation of these cells, suggesting their plasticity can be leveraged for autologous ...

The immune system uses a large number of proteins to sense the presence of microbes, including a family of proteins known as TLRs. The function of TLRs on immune cells known as DCs and macrophages has ...

Clinical trial data have revealed that B cell depletion can be an effective therapy for a number of autoimmune diseases that are typically thought to be T cell dependent, such as type 1 diabetes, ...

Conservation of their respective cytoplasmic tail motifs, CxC/H in the case of CD4 and an ITIM-like motif in the case of LAG-3, supports that competition between CD4 and LAG-3 for binding of kinase ...

DelveInsight has recently added “T-cell Surface Glycoprotein CD4 – Pipeline Insight, 2020,” report to its store that provides detailed insights about 15+ companies and 15+ pipeline drugs in T-cell ...

The T-cell branch of the immune system can respond to a virtually infinite variety of antigens, in part because it includes a very large repertoire of T-cell clones, each with a unique receptor for ...

IL-21 is a type I cytokine essential for immune cell differentiation and function. Although IL-21 can activate several STAT family transcription factors, previous studies focused mainly on the role of ...

Cancer immunotherapy using "designer" immune cells has revolutionized cancer treatment in recent years. In this type of therapy, T cells, a type of white blood cell, are collected from a patient's ...

TUCSON, Arizona — A study led by researchers at the University of Arizona Health Sciences discovered new information about the inner workings of the immune system that could have a profound impact on ...