Opioid Use Linked to Low Testosterone In a Canadian study, more than half of older adults with CKD initiated allopurinol at a higher-than-recommended dose. Allopurinol doses exceeding 100 mg/d may ...

Please provide your email address to receive an email when new articles are posted on . Allopurinol dose escalation for patients with gout did not result in improved survival under the currently ...

March 17, 2005 — High-dose allopurinol can prevent post–endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, according to the results of a randomized study published in the March issue ...

There was an increase in all-cause mortality among dose escalators (hazard ratio, 1.08; 95% confidence interval, 1.01 to 1.17). Similar effect sizes were seen for incidence of cardiovascular-related ...

In a study of patients hospitalized with acute gout flares and who had prescriptions for allopurinol, those who had their allopurinol dosages decreased had a higher rate of gout flares within 3 months ...

Allopurinol is currently used as urate-lowering therapy in patients with gout. Findings suggesting that allopurinol-related toxicity is associated with impaired renal function have led to the ...

Among patients with gout, treatment with at least 300 mg allopurinol daily was associated with a 13% reduced risk for kidney function decline, according to data published in JAMA Internal Medicine.

The 2012 American College of Rheumatology gout treatment guidelines recommend titration of urate-lowering medication doses to achieve target serum uric acid (sUA) levels of less than 6 mg/dL. Analysis ...

In the Febuxostat versus Allopurinol Streamlined Trial (FAST), which was required by the European Medicines Agency, 6128 patients (mean age 71 years; 85.3% men; 99.1% White) were randomly assigned to ...

gout RA in hand Linked to small increase in mortality; at 2 years, 31% of dose escalators achieved serum urate goal. HealthDay News — Allopurinol dose escalation is not associated with reductions in ...

Allopurinol inhibits the generation of oxygen-derived free radicals and it has been postulated that this xanthine oxidase inhibitor might prevent post-endoscopic retrograde cholangiopancreatography ...