UnitedHealthcare CEO Brian Thompson was shot and killed in Midtown Manhattan Wednesday morning in a “brazen, targeted attack” as he walked toward the hotel hosting the company’s annual investor conference,

Police are searching for the assailant, who appeared to be in “lying in wait” before the “brazen, targeted attack.”

Brian Thompson, 50, was outside the hotel on Sixth Avenue when the suspect shot him in the chest and leg around 6:45 a.m.